Dr. Padraig O'Casaigh

(Dr. Patrick Casey)


Date of Birth - 17th June, 1967

Citizenship - New Zealand, Ireland

  • 2019 - Present, Chief Medical Director/ Inventor, Chaperonze LLC Houston, Texas
  • 2015 - Present, Manager/Owner/CSO, Fission Biomedical LLC Advanced Science and Technology Commercialization Center (ASTeCC) University of Kentucky,Lexington 40596, USA
  • 2002 - Present, CEO/Director of Fission Biomedical Ltd, Auckland, New Zealand, Lexington, Kentucky, USA
  • 2003 - Present, Trustee, Clinician/Scientist, Mont Liggins Trust (Previously One Helix Trust), Research Centre in Reproductive Medicine, University of Auckland, Auckland, New Zealand.
  • 1995 - Present, Director of North Western Veterinary Ltd. 522 SH 16, Kumeu, New Zealand.
  • 1993 - Present, Director of UniScience Products Ltd, 522 SH 16, Kumeu, New Zealand.
  • 1993 - Present, Director of Andrology Services, 522 SH 16, Kumeu, New Zealand.
  • 1992 - Present, Scientific Consultant, Auckland, New Zealand
  • 1992 - Present, Research Associate and Honarary Senior Lecturer, Research Centre in Reproductive Medicine, Department of Obstetrics and Gyneacology, University of Auckland, Auckland, New Zealand.

1992 - Present, Undergraduate and supervision of graduate students, University of Auckland, New Zealand, University of California, USA, University of Glasgow, Scotland

1989-1992 Lecturer and Clinical Teacher, School of Veterinary Medicine, UC Davis, Davis California, USA.

  • 1992 - 1995, Post Doctoral Fellow, Department of Veterinary Medical Population Health and Reproduction. U.C. Davis, Davis, California, U.S.A.
  • 1990 - 1992 Ph.D. (Comparative Pathology) U.C. Davis, California, U.S.A.
  • 1989 - 1992 Residency in Equine Reproduction , U.C. Davis, California, U.S.A.
  • 1985 - 1988 B.V.Sc. Massey University, Palmerston North, N.Z.
  • 1984 University Junior Scholarship, Auckland Grammar School, N.Z.

  • Casey P.J., Liu, I.K.M,. Stewart, D.R., & Scott, M.A. (1991) The effects of equine relaxin on sperm longevity and motility in chilled and cryopreserved semen. J. Reprod. Fert., S44: 645-646.
  • Casey, P.J., Robertson, K.R., Liu, I.K.M., Botta E., S., & Drobnis, E.Z. (1992) Column separation of motile spermatozoa from stallion semen. Proc. 37th Ann. Conv. AAEP. 203-210
  • Casey, P.J., Richard, K.A., Robertson, K.R., Liu, I.K.M., & Drobnis, E.Z. (1992) The effect of separation on the motility, viability, longevity and acrosomal status of equine sperm. Proc. Annual Meeting Therio. 128-134.
  • Casey, P.J., Hillman, R.B., Robertson, K.R., Yudin, A.I., Liu, I.K.M., & Drobnis, E.Z. (1993) Validation of an acrosomal stain for equine sperm that differentiates between living and dead sperm. J. Androl. 14:289-97
  • Casey, P.J., Robertson, K.R., Liu, I.K.M., Botta E., S., & Drobnis, E.Z. (1993) Column separation of motile sperm from stallion semen. J. Andrology. 14;142-148
  • Davis, R.O., Gravance, C.G., & Casey, P.J. (1993) Automated morphometric analysis of stallion spermatozoa. A.J.V.R .54;1808-1811
  • Gravance C.G., Lewis K., & Casey P.J. (1995) Computer automated sperm head morphometry analysis (ASMA) of goat spermatozoa. Theriogenology. 44:989- 1002.
  • Gravance C.G., Casey P.J., & Erpino M.J. (1996) Progesterone does not inhibit aggression induced by testosterone metabolites in castrated male mice. Horm. Behav. 30:22-25
  • Gravance, C.G., Vishwanath, R., Pitt, C. and Casey, P.J. (1996) Standardization of computer automated morphometric analysis of bull sperm heads. Theriogenology 46:1205-1215.
  • Gravance, C.G., Liu, I.K.M., Davis, R.O. and Casey, P. J. (1996). Quantification of normal sperm head morphometry in the stallion. J. Reprod. Fertil. 108:41-46.
  • Williamson, C.C., James, E.A., James, M.P., May, C.D., Casey, P.J. (1996) Horse plasma lactate determinations: comparison of wet and dry chemistry methods and the effect of storage. Equine Vet. Journal. 28;5;406-408.
  • Breier, B.H., Vickers, M.H., Gravance, C.G. and Casey, P.J. (1996). Growth hormone (GH) markedly increases the motility of spermatozoa and the concentration of insulin-like growth factor-I in seminal vesicle fluid in the male GH-deficient dwarf rat. Endocrinology 137:4061-4064.
  • Casey, P.J., Gravance, C.G., Davis, R.O., Chabot, D.D. and Liu, I.K.M. (1997). Morphometric differences in sperm head dimensions of fertile and subfertile stallions. Theriogenology 47:575-582.
  • Gravance, C.G,, Robertson, K.R., White, C. and Casey, P.J. (1997). The effects of cryopreservation on the morphometric dimensions of caprine sperm heads. Anim Reprod Sci 49:37-43
  • Gravance, C.G., Breier, B., Vickers, M. and Casey, PJ. (1997). Impaired semen characteristics in post pubertal growth hormone deficient dwarf (dw/dw) rats. Anim Reprod Sci. 49:71-76.
  • Gravance, C.G, Champion, Z.J, and Casey, P.J. (1997) Sperm head morphometry analysis of ejaculate and dismount stallion semen samples. Anim Reprod Sci. 47:149-155.
  • Breier, B.H., Vickers, M.H., Gravance, C.G. and Casey, P.J. (1998). Therapy with growth hormone: major prospects for the treatment of male subfertility. Endocr. J 45 Suppl:S53-60.
  • Gravance, C.G, Sax-Gravance, S.K., Champion, Z.J. and Casey, P.J. (1998) Percentage of normal sperm heads is significantly increased by Percoll separation of semen. Int J Androl. 21:116-119.
  • Gravance C.G., Vishwanath R, Pitt C, Garner DL, Casey PJ (1998) Effects of cryopreservation on bull sperm head morphometry. J Androl 19:704-709.
  • Gravance CG, Champion ZJ, Casey PJ (1998) Computer-assisted sperm head morphometry analysis (ASMA) of cryopreserved ram spermatozoa. Theriogenology 15;49(6):1219-30.
  • Gravance CG, Garner DL, Pitt C, Vishwanath R, Sax-Gravance SK, Casey PJ (1999) Replicate and technician variation associated with computer aided bull sperm head morphometry analysis. Int J Androl 22:77-82
  • Vickers MH, Casey PJ, Champion ZJ, Gravance CG, Breier BH (1999). IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat. Growth Horm IGF Res ;9(4):236-40
  • Champion ZJ, James EA, Vickers MH, Breier BH, Casey PJ (2000). The Effects of Bovine Recombinant Growth Hormone Administration on Insulin-like Growth Factor-I and the Haemopoietic System in Thoroughbred Geldings. Vet J. ;160(2):147-152.
  • Champion ZJ, Breier BH, Ewen WE, Tobin TT, Casey PJ (2002). Blood Plasma Concentrations of Insulin-like Growth Factor-I (IGF-I) in Resting Standardbred Horses. Vet J. ;163(1):45-50.
  • Champion ZJ, Vickers MH, Gravance CG, Breier BH, Casey PJ (2002). Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. Theriogenology.;57(7):1793-800.
  • Gunn MR, Champion Z, Casey ME, Teal P, Casey PJ (2007) Testicular and spermatozoan parameters in the pukeko (Porphyrio porphyrio melanotus). Anim Reprod Sci. (2008) Dec;109(1-4):330-42. Epub 2007 Nov 19
  • Patrick Casey, Richard Fry, Kerri Fry, James Vanner and Mary Casey (2008). Treatment of tendon rupture by auto transplantation. Proc NZVA 109-112
  • Wendy A. Spencer, Fernanda C. Camargo, Wojtek Karpiesiuk, Charlie Hughes,; Kent H. Stirling, Patrick J. Casey,; and Thomas Tobin. (2008). Review of the Current Status of Thresholds/Withdrawal Time Guidelines for Therapeutic Medications in Performance Horses. Proc. 54th Ann. Conv. AAEP. 29-37 Vol 54
  • Gravance CG, Casey ME, Casey PJ. (2009). Pre-freeze bull sperm head morphometry related to post-thaw fertility. Anim Reprod Sci. 2009 Aug;114(1-3):81-8. Epub 2008 Oct 1
  • Casey PJ (2011) . A New Generation of Tenocytes Grown In-Vitro to Effect Tendon Repair and Regeneration. Proc. European Veterinary Conference, 287-288
  • Pereira GR, Lorenzo PL, Carneiro GF, Ball BA, Gonçalves PB, Pegoraro LM, Bilodeau-Goeseels S, Kastelic JP, Casey PJ, Liu IK. (2012). The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes. Zygote. 2012 Nov;20(4):353-60.
  • G.R. Pereira , http://www.sciencedirect.com/science/article/pii/S0034528813002233 - af005   P.L. Lorenzo b ,  G.F. Carneiro a ,  B.A. Ball a ,  S. Bilodeau-Goeseels c ,  J. Kastelic c ,  L.M.C. Pegoraro d ,  C.A. Pimentel e ,  A. Esteller-Vico b ,  J.C. Illera b ,  G.S. Granado b ,  P. Casey f , I.K.M. Liu (2013) The involvement of growth hormone in equine oocyte maturation, receptor localization and steroid production by cumulus–oocyte complexes in vitro. Research in Veterinary Science Volume 95, Issue 2 , October 2013, Pages 667–674
  • C.K. Fenger1, T. Tobin, P.J. Casey, E.A. Roualdes, J.L. Langemeier1 and D.M. Haines (2014) Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds Comparative Exercise Physiology; 10 (4): 233- 238
  • C.K. Fenger1, T. Tobin, P.J. Casey, E.A. Roualdes, J.L. Langemeier1, R Cowles and D.M. Haines (2016) Enhanced Bovine Colostrum Supplementation Shortens the Duration of Respiratory Disease in Thoroughbred Yearlings. Journal of Equine Veterinary Science 42

Method for growing adult cells

Patent number: 8372644

Abstract: A method for growing adult cells includes harvesting a tissue sample from a subject and breaking the tissue sample into fragments. The fragments are placed into a culture vessel, and at least some of the fragments are induced to adhere to the culture vessel. The fragments are supplied with nutrients so that adult cells contained therein divide and grow.

Type: Grant

Filed: February 6, 2007

Date of Patent: February 12, 2013

Assignee: Transplantation Limited

Inventors: Patrick J. Casey, Richard Fry, Kerri Fry

Contraceptive Vaccines for Mammals

Patent number: 9649367

Abstract: Abstract: The invention provides a contraceptive vaccine for a  female  recipient of a target species of mammals including a composition of at least one of a plurality of granulosa cells and a plurality of ovarian stromal cells in combination with an adjuvant; wherein the cells are grown from a tissue  sample  of the cells obtained from at least one female donor of the target species which is not the same individual as the female recipient. The invention also provides a method of producing the contraceptive vaccine as well as a method of treating a female recipient with the contraceptive vaccine to prevent pregnancy.

Type: Grant

Filed: March 21, 2014

Date of Patent: May 16, 2017


Inventors: Patrick J. Casey, Irwin K. M. Liu

New Zealand Blood Horse, New Zealand Horse and Pony, New Zealand Equine Branch Newsletter (Veterinary), New Zealand Herald, Lexington Herald-Leader (USA), New Zealand Miniture Horse Society Newsletter, TB of California (USA), Horse Report (UC Davis, Ca, USA), Delaware Daily News (USA), The Press (Christchurch, New Zealand), Sunday News (NZ), Sunday Star Times (NZ), NorWest Newsbrief (Kumeu, NZ), GP Monthly (NZ), Western Australian Times (Aus), Fibre News (NZ), Otago Daily Times (NZ), Waikato Times (NZ), Western Leader (NZ), American Blood Horse, Northern Advocate (NZ), Evening Standard (NZ), New York Times (US), Journal of Life Sciences, Hoof Beats, USA

  • Australian Public Radio - Topic - “Advances in the diagnosis of male fertility”
  • New Zealand Public Radio - Topics
    1. “Advances in the diagnosis of male fertility”
    2. “New methods of drug detection in racing”
    3. “The detection of growth hormone administration”
    4. “Preservation of endangered Native birds”
    5. “Native Bird Preservation”
  • Newstalk ZB -Topic - “Tertiary education in New Zealand vs North America”
  • Auckland Access Radio - Topic - “Detection of milkshakes in racing”
  • Auckland Community Radio - Topic - “Sperm”
  • British Broadcasting Corp. (BBC) - “Preservation of endangered Native birds”
  • Radio Massey - “Saint Patrick and his role in our daily lives”
  • Radio Live – “Green Kiwi Day”
  • National Public Radio (USA) Topic “Growing Tendons”
  • Television New Zealand - Topics
    1. “Diagnosis of male fertility”
    2. “Detection of growth hormone”
    3. “Detection of milkshakes in horses”
    4. “Preservation of endangered Native birds”
    5. “Irish Music”
  • Lexington Channel 4 (USA) Topic - “Rugby in America”

  • New Zealand Sport Horse Association
  • New Zealand Miniature Horse Association
  • Auckland Miniature Horse Association
  • Thoroughbred Owners and Trainers Assocation
  • Combined Conference of New Zealand Racing Authorities
  • Dargaville Racing Club
  • Rotary Clubs (Various)
  • Schools (All ages, Various)
  • Pony Clubs (Various), Maryland Standardbred Trainers Association, Waikato Thoroughbred Breeders Association
  • “Equitainer”, Victoria, Australia
  • Victoria Breeders Association
  • Victorian Equine Vetererinary Association
  • New Zealand Veterinary Association
  • Kentucky Equine Pracractioners Association
  • Oldenberg Equine Pracractioners Association
  • European Veterinary Association
  • World Stem Cell Congress
  • Asian Autism Society

Mont Liggins Trust Research Centre in Reproductive Medicine Department of Obstetrics and Gyneacology University of Auckland Private Bag, Auckland, New Zealand.

Consultant to John Hughes Chair Health Science Drive, UC Davis Davis Ca.95616, USA

Fission Biomedical LLC Advanced Science and Technology Commercialization Center (ASTeCC) University of Kentucky Lexington 40596, USA