Cellular renewal · Made in New Zealand

Age is a cellular story. Rewrite it.

Chaperonze delivers chaperone proteins — your cells' own repair crew — to help them clear the clutter of time and work like they used to.

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Understanding the biology

Meet the proteins that keep you young.

Your body is built from trillions of cells, and every one runs on proteins. But a protein only works when it's folded into exactly the right shape — and many can't fold themselves. That's the job of chaperone proteins.

i. — Viability

They fold

Chaperone proteins guide amino-acid chains into their correct, functional shapes. Without them, proteins misfold, clump together and crowd the cell — and the cell's health declines.

ii. — Rejuvenation

They clean up

Stress and time turn good proteins into junk. Chaperones act as the cell's controllers — identifying that junk and either repairing it or clearing it out.

iii. — Defence

They scavenge free radicals

Chaperones are the cell's natural free-radical scavengers, easing the oxidative stress that accumulates with age.

iv. — Longevity

They protect telomeres

Telomeres — the protective caps on our chromosomes — shorten with every division, and oxidative stress shortens them faster. By reducing that stress, chaperones help protect them.

Why we age

As a cell ages, it loses its chaperone proteins. Damaged proteins and free radicals pile up. The cell grows more toxic — and we feel it as lower energy, aches, and the visible signs of time.

Watch the film · 0:25

How Chaperonze works

Repair, one cell at a time.

Chaperonze is the only commercially available product containing chaperone proteins — applied simply, to the wrists.

Apply

Freeze-dried chaperone protein powder is mixed with a specialised Protein Transfer Oil, made from emu oil, and applied to the wrists.

Travel

The oil carries the proteins across the skin barrier and into the bloodstream, where cells signal for them through a process called tropism.

Renew

Inside the cell, the proteins get to work stabilising, repairing and regenerating — targeting the causes of aging, not just its symptoms.

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Research history

From the racetrack to the cell.

Chaperonze began with a boy at the horse races in New Zealand, curious about what stallions inherited from their parents. It became a three-decade search for why cells stop working — and how to start them again.

1989

Kentucky

Fresh from veterinary school, 21-year-old Dr. Patrick Casey takes an equine surgery internship at Hagyard, Davidson & McGee in Lexington — and meets Dr. Umphenour, a friend for the next 30 years.

1990s

UC Davis & the growth hormone axis

During a residency, PhD and postdoc at UC Davis, his group becomes the first to show that the growth hormone (GH) axis is key to male fertility in mammals. But some older stallions simply won't respond to GH. Why?

2000s

Growing adult cells

Nature regrows after an insult — pruned roses, forests after fire, altitude training. Applying that idea to cells leads to his patent, Method for Growing Adult Cells. The new cells, he finds, are packed with chaperone proteins.

Theory

A unified theory of aging

As chaperones are lost, cells clog with "junk protein". The DNA hasn't changed — its message just can't get through. Those unresponsive stallions? Their cells were too clogged to make use of GH.

2019

Chaperonze

After developing extraction, a treatment method and blood-based biomarkers across horse, human and cat models, Chaperonze LLC launches in Houston, Texas.

"How do you tell a cell that has stopped dividing that it can start again?"

Dr. Padraig O'Casaigh (Dr. Patrick Casey) — Inventor & Chief Medical Director
BVSc · PhD, Comparative Pathology (UC Davis) · MRCVS

Comparison with stem cells

Not new cells. Better ones.

Stem cell therapy

Introduces new cells

Unspecialised cells that can become other cell types
Risk the body treats them as foreign and rejects them
Exciting promise, but significant technical hurdles remain

Chaperonze

Renews the cells you have

Works with your body's existing cells
Supports their own repair and regeneration
Natural proteins, applied topically to the wrist

The treatment

Twenty minutes. Once a week.

One course is a single application each week for four weeks, repeated every three months — giving your cells time to repair, regenerate and reorganise between courses.

Blue · Protein powderRed · Transfer oil

Open both vials. Make sure the red (oil) vial is at room temperature.
Mix. Pour the oil into the powder, cap the vial, and mix thoroughly by inverting.
Apply. Spread lightly on both wrists and let it absorb for 20 minutes.
Rinse. Wash any residue off with water.

Never heat the oil or powder — heat can damage the proteins.

1× weekly4 weeks per courseRepeat every 3 months

All-natural, made in New Zealand with the New Zealand Government at a GMP facility, in accordance with USDA, EU and Halal rules. Made under licence by Pacific BioScience Ltd, Kumeu.

Mitochondrial transplantation

A unique process for longevity.

Mitochondria are the power plants of every cell. Our research pairs Chaperonze with a transplant of healthy mitochondria, aimed at longevity and the alleviation of disease. The work comes from Dr. Casey's research group at the Mont Liggins Trust, University of Auckland.

Summary

Aging is biologic, not chronologic

As cells age, their mitochondria become unstable
Toxins (ROS) and damaged proteins build up inside the cell
Chaperonze clears that debris to reset the cell's operating system

Summary II

Transplant superior mitochondria

Introduce healthy, "superior" mitochondria
Let the body's natural reproduction make 10 trillion more
Use the blood system to carry them to every cell
This can aid in reversing cellular age and alleviating disease

Whole body distribution

From the bone marrow to every tissue.

Target

Donor mitochondria are directed to the body's progenitor cells, helped by chaperone protein treatment.

Multiply

The mitochondria are incorporated into those cells and multiply as the cells reproduce.

Distribute

The blood network carries them out to all of the body's tissues.

Clinical protocol

Four months, start to finish.

4months total

Month 1Chaperonze treatmentPrepares the cells

ThenMitochondrial transplantHealthy mitochondria introduced

Months 2–4Chaperonze treatmentSupports uptake and renewal

Results & biomarkers

Measured in the blood.

We track two key biomarkers to measure how the treatment is working.

HSP70

Chaperone Protein Axis

As cells age they become slightly "porous" and HSP70 leaks into the bloodstream — so circulating HSP70 rises as cells become impaired. Chaperonze increases HSP70 inside the cell, stabilising it, and circulating levels come down.

IGF-1

Growth Hormone Axis

IGF-1 declines with age, which our research links to an overall decline in cellular function. As cellular health improves, we believe key hormonal function follows.

Since using Chaperonze my libido has improved, as has my overall energy level. Last night I got an uninterrupted night's sleep. I would advise anyone to take this game-changing treatment.

Mr. Rich, USA

I cannot remember a time that I had nothing wrong with me for such an extended period — not even a cough or a cold. It's incredible.

Dr. Umphenour, USA

I can't believe how good I feel since I began using Chaperonze. I have not felt or looked this good since my thirties!

Ms. Jane, USA

Individual experiences. Results vary from person to person.

Beyond humans

Trusted across species.

Veterinary clinicians use Chaperonze too. If you're interested in treatment for your animal, get in touch.

Horses

Used for musculoskeletal injuries — often ligament and tendon related, and often career-ending — and for age-related decline. Dr. Casey's group ran the largest study of aging and the chaperone axis in horses.

Cats

Used by clinicians to support kidney health in older cats and to help with other age-associated conditions.

Dogs

Used in older dogs, where aging shows up in many clinical ways — working at the cellular level so the body can repair and regenerate.

Academic roots

Built in the lab.

Collaborating universities

UC Davis California, USA

University of Auckland New Zealand

University of Kentucky Kentucky, USA

Medical seminars

Nov 2017 · Singapore

Chaperone Proteins — Mechanisms, Functions and their Clinical Applications

11th World Congress, Regenerative Medicine & Stem Cell

Mar 2018 · Chiang Mai, Thailand

The Role of Chaperone Proteins in Gene Expression and Disease Treatment

Autism: Learning Difficulties and Development Disabilities

Feb 2019 · Dar es Salaam, Tanzania

Chaperone Proteomic Therapy for Heart Failure and End-stage Kidney Diseases

1st International Medical Conference on Genomics, Proteomics & Medical Innovations

Jun 2019 · Thailand

Chaperones — Intracellular Rejuvenating Proteins. New Rising in Regenerative Medicine

Vita Stem Academy

Our team

The people behind it.

Dr. Padraig O'Casaigh

Chief Medical Director · Inventor

The brain and chief researcher behind Chaperonze. CEO of Fission Biomedical; Honorary Senior Lecturer, University of Auckland.

Aida Dagher

President

Jabour Bakla

Vice President

Three decades running businesses across clothing, jewellery, entertainment and real estate. Partner in Chaperonze.

Jaafar Sultan

Sales Director

Two decades in executive business development and sales across healthcare and banking, focused on Europe, the GCC and the Middle East.

Dana Saab

Marketing Director

A decade-plus in marketing, including Ogilvy. MSc International Marketing Management, Boston University.

Babu Pothen

Administration Director

Two decades in office administration with UBS, Credit Suisse and leading investment firms across the GCC.

Begin your renewal.

Questions about the treatment, ordering, or veterinary use? Leave your details and our team will be in touch.

Call+1 713 280 0675

Emailinfo@chaperonze.com

Visit

3255 Westwick Drive
Houston, Texas 77082, USA